Adult dolutegravir doses in children

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No clinically significant pharmacokinetic interactions between dolutegravir and daclatasvir in healthy adult subjects

BACKGROUND Daclatasvir (DCV) is an NS5A replication complex inhibitor recently approved for chronic hepatitis C virus treatment. METHODS To assess drug interactions between the HIV integrase strand transfer inhibitor dolutegravir (DTG) and DCV, subjects were randomized into 1 of 2 sequences in an open-label, 3-period, crossover study. Subjects received either DTG 50 mg once daily or DCV 60 mg...

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ژورنال

عنوان ژورنال: The Lancet HIV

سال: 2020

ISSN: 2352-3018

DOI: 10.1016/s2352-3018(20)30194-6